Hydrochloric Acid → N-(4-methanesulfonylamino-3-vinyl-benzyl)-2,3-diphenyl-propionamide
Reaktionsgleichung
[CH3:1][S:2]([NH:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH2:11])=[CH:8][C:7]=1[CH:14]=[CH2:15])(=[O:4])=[O:3].Cl.[C:17]1([C:23](=[CH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:24](O)=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH3:1][S:2]([NH:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH:11][C:24](=[O:25])[CH:23]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:8][C:7]=1[CH:14]=[CH2:15])(=[O:4])=[O:3]Komponenten
4
Versuchsvorschrift
4-Methanesulfonylamino-3-vinylbenzylamine and HCl salt (131 mg, 0.499 mmol) were reacted with 2,3-diphenyl-acrylic acid (115 mg, 0.512 mmol) prepared by the reported procedure to give N-(4-methanesulfonylamino-3-vinyl-benzyl)-2,3-diphenyl-propionamide (146 mg, 68%).