N-Methylethylamine → 4-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide

HRID 2358698Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2358698
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[CH3:21][NH:22][CH2:23][CH3:24]>C(Cl)Cl>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([N:22]([CH2:23][CH3:24])[CH3:21])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

Komponenten

4

Edukt 2

HCID 12219N-MethylethylamineHCID 866154944-(4-Chloro-2-nitrophenoxy)benzoyl chloride

Produkt 1

HCID 684597124-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

The compound from Example 126c (1.0 g, 3.2 mmol) in CH2Cl2 was added to a mixture of N-methylethanamine (379 mg, 6.41 mmol) in CH2Cl2. Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound, which was purified by silica gel column chromatography eluting with 50% EtOAc/hexane giving a yellow oil (1.03 g, 100%).

Aufarbeitung

  1. concentrationMixture was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b5950ceb20154c2c966813f1148fbd05
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07763731B2

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