Benzylamine → HCID 67261084, Verbindung

HRID 2359042Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2359042
[Cl:1][C:2]1[S:6][C:5]([C:7]2[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[C:14](S(C)(=O)=O)[N:13]=3)=[CH:10][N:9]([CH:22]([CH3:24])[CH3:23])[N:8]=2)=[CH:4][CH:3]=1.[CH2:25]([NH2:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([NH:32][C:14]1[N:13]=[C:12]([C:11]2[C:7]([C:5]3[S:6][C:2]([Cl:1])=[CH:3][CH:4]=3)=[N:8][N:9]([CH:22]([CH3:24])[CH3:23])[CH:10]=2)[CH:17]=[CH:16][N:15]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Komponenten

3

Edukt 2

HCID 7504BenzylamineHCID 67260704HCID 67260704, Verbindung

Produkt 1

HCID 67261084HCID 67261084, VerbindungAusbeute 96 %

Versuchsvorschrift

A mixture of 4-[3-(5-chloro-2-thienyl)-1-isopropyl-1H-pyrazol-4-yl]-2-(methylsulfonyl)pyrimidine (1 eq, 5.2 mmol) in 25 mL benzylamine was stirred overnight at room temperature. The solvent was evaporated and the residue was diluted in dichloromethane and washed three times with HCl 1M. The organic layer was then dried over MgSO4 and evaporated to afford 2.3 g of N-benzyl-4-[3-(5-chloro-2-thienyl)-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-amine (96% yield).

Aufarbeitung

  1. customThe solvent was evaporated
  2. additionthe residue was diluted in dichloromethane
  3. washwashed three times with HCl 1M
  4. dry with materialThe organic layer was then dried over MgSO4
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-69a9e99851844966ba2b881130057480
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08685974B2

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