Dimethylformamide dimethyl acetal → HCID 67260579, Verbindung

HRID 2359062

Reaktionsgleichung

Reaktionsgleichung von HRID 2359062
[CH3:1][C:2]1[CH:3]=[C:4]([C:7](=[O:9])[CH3:8])[S:5][CH:6]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH3:12][N:13]([CH3:15])[CH:14]=[CH:8][C:7]([C:4]1[S:5][CH:6]=[C:2]([CH3:1])[CH:3]=1)=[O:9]

Komponenten

3

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 836541-(4-Methyl-2-thienyl)ethan-1-one

Produkt 1

HCID 67260579HCID 67260579, VerbindungAusbeute 100 %

Versuchsvorschrift

A mixture of 1-(4-methyl-2-thienyl)ethanone (70.8 mmol) and N,N-dimethylformamide dimethyl acetal (105.1 mmol) was refluxed overnight and then allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure and dried in vacuo to afford 13.8 g (100% yield) of 3-(dimethylamino)-1-(4-methyl-2-thienyl)prop-2-en-1-one which was used in the next step without further purification.

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5059afaa48714899a0071ff605fd7a13
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08685974B2

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