(4-Cyano-3-fluorophenyl)boronic acid → HCID 53339261, Verbindung
Reaktionsgleichung
Br[C:2]1[CH:7]=[CH:6][N:5]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[N:10]=[C:4]2[N:3]=1.[C:15]([C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[F:26])#[N:16]>>[N:3]1[C:4]2[N:5]([C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[N:10]=2)[CH:6]=[CH:7][C:2]=1[C:20]1[CH:21]=[CH:22][C:17]([C:15]#[N:16])=[C:18]([F:26])[CH:19]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared using General Experimental Procedure A (Suzuki coupling reaction) from 2-bromobenzo[4,5]imidazo[1,2-a]pyrimidine and (4-cyano-3-fluorophenyl)boronic acid on a 0.1 mmol scale. The residue was washed with water (3×5 mL), EtOAc (3×2 mL), and DCM (3×2 mL) and dried under high vacuum to afford 4-(Benzo[4,5]imidazo[1,2-a]pyrimidin-2-yl)-2-fluorobenzonitrile (T747) as a orange solid (10 mg, 35%). 1H NMR (400 MHz, DMSO-d6): δ 9.74 (d, J=6.8 Hz, 1H), 8.46 (d, J=10.8 Hz, 1H), 8.41-8.38 (m, 2H), 8.19 (t, J=7.6 Hz, 1H), 7.98 (d, J=6.8 Hz, 1H), 7.90 (d, J=8.4 Hz, 1H), 7.60 (t, J=7.2 Hz, 1H), 7.45 (t, J=7.2 Hz, 1H); MS (ESI) m/z [M+H]+289.