Benzene → 5-(p-Chlorophenyl)-2-furoic Acid 2,2-Dimethylhydrazide
Reaktionsgleichung
C[NH:2][NH:3][CH3:4].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[O:16][C:15]([C:17](Cl)=[O:18])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[CH:20]1C=CC=CC=1>>[CH3:20][N:3]([CH3:4])[NH:2][C:17]([C:15]1[O:16][C:12]([C:9]2[CH:10]=[CH:11][C:6]([Cl:5])=[CH:7][CH:8]=2)=[CH:13][CH:14]=1)=[O:18]Komponenten
4
Versuchsvorschrift
To a solution of 36 g (0.60 mole) of dimethylhydrazine and 150 ml of benzene was added portionwise 60 g (0.25 mole) of 5-(p-chlorophenyl)-2-furoyl chloride with the temperature being controlled below 50° by means of an ice bath. The reaction mixture was refluxed for 2 hours with dissolution, cooled and the resulting precipitate filtered, washed with water and dried at 60° to yield 48 g (73%). An analytical sample was prepared by recrystallizing a sample from ethyl acetate/Darco and drying in the vacuum pistol at room temperature, m.p. 150°-152°.