Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone

HRID 2362805Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2362805
[Cl:1]N1C(=O)CCC1=O.[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]>CN(C=O)C>[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:1])[C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-one

Produkt 1

HCID 594970741-butyl-3-chloro-4-hydroxy-2(1H)-PyridinoneAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction mixture was stirred overnight at room temperature and was then concentrated in vacuo. The crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D6 (2.0 g, 83%).

Aufarbeitung

  1. concentrationwas then concentrated in vacuo
  2. customThe crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent)

Quellen und Nachweise

ORD-Eintrag
ord-32c1fd10ba544846ad7a947bf40dba39
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08691849B2

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