Hydrochloric Acid → 2-(3-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone

HRID 236281

Reaktionsgleichung

Reaktionsgleichung von HRID 236281
[NH:1]([C:3]1[NH:12][C:11](=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)[NH2:2].CO[CH:16](OC)[CH2:17][C:18](=O)[CH3:19].Cl>C(O)C>[CH3:19][C:18]1[CH:17]=[CH:16][N:1]([C:3]2[NH:12][C:11](=[O:13])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[N:4]=2)[N:2]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 2285484,4-Dimethoxy-2-butanoneHCID 1354496132-Hydrazinyl-3,4-dihydroquinazolin-4-one

Produkt 1

HCID 1357821512-(3-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

35.2 g (0.2 mole) of 2-hydrazino-4(3H)-quinazolinone, 500 ml of ethanol and 31.68 g (0.24 mole) of 4,4-dimethoxy-butan-2-one are boiled under reflux for 4.5 hours. The initial suspension has then dissolved. The same volume of 2 N HCl at 50° is added at 50°, whereupon a precipitate soon forms. After warming at 50° for a total of 40 minutes, the 2-(3-methyl-1H-pyrazol-1-yl)-4(3H)-quinazolinone is isolated by filtration with suction. The crude product (35.9 g of melting point 162° to 165° C.) is recrystallized from ethanol and then has a melting point of 165° to 166° C.

Aufarbeitung

  1. temperatureunder reflux for 4.5 hours
  2. temperatureAfter warming at 50° for a total of 40 minutes

Quellen und Nachweise

ORD-Eintrag
ord-2d330b0118dd4d29bb8bc8721630b65a
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04644000

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