Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid

HRID 236370

Reaktionsgleichung

Reaktionsgleichung von HRID 236370
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH:18](C(OCC)=O)[C:19]([O:21]CC)=[O:20])([O-:3])=[O:2].Cl>O1CCOCC1>[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([OH:21])=[O:20])([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 13408230Diethyl 2-nitro-4-benzoylphenylmalonate

Produkt 1

HCID 137705362-Nitro-4-benzoylphenylacetic acidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.

Aufarbeitung

  1. additionA mixture of 14 g
  2. temperatureto reflux for 10 hours
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. customthe crude product was triturated with hot methylene chloride, 9.88 g

Quellen und Nachweise

ORD-Eintrag
ord-d19d22f9d8d14e5bb46699305da9114a
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04644005

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