Ethyl 2-nitro-4-benzoylphenylacetate → Ethyl 2-amino-4-benzoylphenylacetate

HRID 236372

Reaktionsgleichung

Reaktionsgleichung von HRID 236372
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])([O-])=O>[Ni].C(O)C>[NH2:1][C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

Komponenten

4

Edukt 1

HCID 13770535Ethyl 2-nitro-4-benzoylphenylacetate

Produkt 1

HCID 13770537Ethyl 2-amino-4-benzoylphenylacetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 14 g. (44.7 mmoles) of ethyl 2-nitro-4-benzoylphenylacetate in 225 ml. of ethanol was added 15 g. of wet Raney nickel and the mixture heated to reflux for 1.5 hours. The mixture was filtered and the filtrate concentrated to give a residual oil which was induced to crystallize by trituration with diethyl ether, 7.9 g., m.p. 150°-152° C.

Aufarbeitung

  1. temperatureto reflux for 1.5 hours
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate concentrated
  4. customto give a residual oil which
  5. customto crystallize by trituration with diethyl ether, 7.9 g

Quellen und Nachweise

ORD-Eintrag
ord-1236173910b142118fc888e02d448121
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04644005

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