Tetrahydrofuran → 4,4'-(1-(4-Fluorophenyl)pyrrolidine-2,5-diyl)dibenzene-1,2-diamine

HRID 2364789Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2364789
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]([C:13]3[CH:19]=[CH:18][C:16]([NH2:17])=[C:15]([N+:20]([O-])=O)[CH:14]=3)[CH2:11][CH2:10][CH:9]2[C:23]2[CH:29]=[CH:28][C:26]([NH2:27])=[C:25]([N+:30]([O-])=O)[CH:24]=2)=[CH:4][CH:3]=1.C1COCC1>CN(C=O)C.[Pt]=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:9]([C:23]3[CH:24]=[C:25]([NH2:30])[C:26]([NH2:27])=[CH:28][CH:29]=3)[CH2:10][CH2:11][CH:12]2[C:13]2[CH:14]=[C:15]([NH2:20])[C:16]([NH2:17])=[CH:18][CH:19]=2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 8028TetrahydrofuranHCID 596167834,4'-(1-(4-Fluorophenyl)pyrrolidine-2,5-diyl)bis(2-nitroaniline)

Produkt 1

HCID 596166404,4'-(1-(4-Fluorophenyl)pyrrolidine-2,5-diyl)dibenzene-1,2-diamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The product from Example 29C (0.218 g, 0.50 mmol) was dissolved in DMF (5 mL) then platinum oxide (0.226 g, 0.99 mmol) was added via THF slurry. The flask was evacuated and purged with nitrogen twice, then evacuated and opened to hydrogen balloon. The mixture was stirred at room temperature for 20 h. The solution was taken on to the next step without purification.

Aufarbeitung

  1. customThe flask was evacuated
  2. custompurged with nitrogen twice
  3. customevacuated
  4. customThe solution was taken on to the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-524bf80566984f5b9a1a20de7ca650db
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08691938B2

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