2-Iodoxybenzoic acid → HCID 62501749, Verbindung

HRID 2366189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2366189
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=1.I(C1C=CC=CC=1C(O)=O)(=O)=O>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[S:10][CH:11]=[C:12]([CH:14]=[O:15])[N:13]=1

Komponenten

4

Edukt 2

HCID 1087942-Iodoxybenzoic acidHCID 39347891HCID 39347891, Verbindung

Produkt 1

HCID 62501749HCID 62501749, VerbindungAusbeute 93,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a stirred solution of (2-(2-chloro-6-fluorophenyl)thiazol-4-yl)methanol (5.8 g, 24 mmol) in EtOAc (200 mL) at room temperature was added 2-iodoxybenzoic acid (12.5 g, 44.6 mmol). The resulting mixture was heated at 70° C. for 18 hours. After cooling to room temperature, the residual solid was removed via filtration and the filtrate was concentrated under reduced pressure to give the crude desired product as a white solid (5.4 g, 93% yield) which was used in the next step without further purification.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. customthe residual solid was removed via filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bf8dfd389e81434c8fe3c0e4a7b4c9fa
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08697708B2

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