Hydrochloric Acid → (Z)-2-(3,4-dimethoxy-phenyl)-3-[5-(4-hydroxy-piperidin-1-yl)-thiophen-2-yl]-acrylonitrile hydrochloride

HRID 2366371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2366371
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][CH:24]([OH:27])[CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:22][CH2:23][CH:24]([OH:27])[CH2:25][CH2:26]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 16757522(Z)-2-(3,4-dimethoxyphenyl)-3-(5-(4-hydroxypiperidin-1-yl)thiophen-2-yl)acrylonitrile

Produkt 1

HCID 67228445(Z)-2-(3,4-dimethoxy-phenyl)-3-[5-(4-hydroxy-piperidin-1-yl)-thiophen-2-yl]-acrylonitrile hydrochlorideAusbeute 87 %

Versuchsvorschrift

0.1N Hydrochloric acid (3.0 mL) was added to Compound 6 (100 mg), and purified water (5 mL), acetonitrile (30 mL), and chloroform (5 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred at room temperature for 1 hour, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 95 mg, 87%).

Aufarbeitung

  1. custompurified water (5 mL), acetonitrile (30 mL), and chloroform (5 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customby thoroughly drying

Quellen und Nachweise

ORD-Eintrag
ord-1904d94b84f54ce68cec1518347fe05e
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08697742B2

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