Hydrochloric Acid → (Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile hydrochloride

HRID 2366378Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2366378
[ClH:1].[NH2:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12](/[CH:14]=[C:15](/[C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=3)\[C:16]#[N:17])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1>>[ClH:1].[NH2:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12](/[CH:14]=[C:15](/[C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=3)\[C:16]#[N:17])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 11842656(Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile

Produkt 1

HCID 67226969(Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile hydrochlorideAusbeute 96 %

Versuchsvorschrift

0.1N Hydrochloric acid (3.7 mL) was added to Compound 22 (117 mg), and purified water (30 mL), acetonitrile (30 mL), and chloroform (5 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred at room temperature for 1 hour, and the solvent was evaporated to dryness. The residue was suspended in hexane-ethyl acetate, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 124 mg, 96%).

Aufarbeitung

  1. custompurified water (30 mL), acetonitrile (30 mL), and chloroform (5 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customthe solvent was evaporated to dryness
  6. customby thoroughly drying

Quellen und Nachweise

ORD-Eintrag
ord-1aaf467c33b14aa2887449371b344046
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08697742B2

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