6-Chloro-N~4~,N~4~-dimethylpyrimidine-2,4-diamine → HCID 58504374, Verbindung

HRID 2367207Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2367207
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[C:6]([F:10])[C:7]=1[CH:8]=[O:9].Cl[C:15]1[N:20]=[C:19]([NH2:21])[N:18]=[C:17]([N:22]([CH3:24])[CH3:23])[CH:16]=1>CCOC(C)=O>[NH2:21][C:19]1[N:20]=[C:15]([C:4]2[CH:3]=[C:2]([F:1])[C:7]([CH:8]=[O:9])=[C:6]([F:10])[CH:5]=2)[CH:16]=[C:17]([N:22]([CH3:24])[CH3:23])[N:18]=1

Komponenten

4

Edukt 2

HCID 2517356-Chloro-N~4~,N~4~-dimethylpyrimidine-2,4-diamineHCID 162177083,5-Difluoro-4-formylphenylboronic acid

Produkt 1

HCID 58504374HCID 58504374, VerbindungAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The title compound was prepared following the General Procedure A using: (3,5-difluoro-4-formylphenyl)boronic acid (2.37 g, 12.8 mmol) and 6-chloro-N4,N4-dimethyl-2,4-pyrimidinediamine (2.2 g, 12.8 mmol). The solid was dissolved in EtOAc and precipitated with hexanes. The resulting solid was collected via vacuum filtration to afford the title compound (2.82 g, 80%) as a yellow solid. LC-MS (ES) m/z=279 [M+H]+.

Aufarbeitung

  1. customThe title compound was prepared
  2. customprecipitated with hexanes
  3. filtrationThe resulting solid was collected via vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-70a2ee2b89f1414c84b29acd83ab527d
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08697685B2

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