Diethyl 2-((2-bromo-4-cyanophenylamino)methylene)malonate → HCID 178469455, Verbindung

HRID 2367656Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2367656
[Br:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:11]=[C:12]([C:18]([O:20]CC)=O)[C:13]([O:15][CH2:16][CH3:17])=[O:14]>C1(OC2C=CC=CC=2)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[C:4]2[C:3]=1[N:10]=[CH:11][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:18]2[OH:20]

Komponenten

3

Edukt 1

HCID 66823182Diethyl 2-((2-bromo-4-cyanophenylamino)methylene)malonate

Produkt 1

HCID 178469455HCID 178469455, VerbindungAusbeute 130,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7583Diphenyl EtherLösungsmittel

Versuchsvorschrift

100 mL of diphenyl ether was heated to reflux followed by addition of 5.00 g (13.6 mmol) diethyl 2-((2-bromo-4-cyanophenylamino)methylene)malonate in portions in 30 minutes. The resulting brown solution was reflux for another hour and then cooled down to room temperature. The precipitate was collected and washed with hexanes (15 mL×3) to give 5.69 g of a light brown solid as the desired product. MS ESI (m/z) 321 (M+1)+.

Aufarbeitung

  1. temperatureto reflux
  2. temperatureThe resulting brown solution was reflux for another hour
  3. customThe precipitate was collected
  4. washwashed with hexanes (15 mL×3)

Quellen und Nachweise

ORD-Eintrag
ord-8df4cd917c4c454cbf0df90f444050d8
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08697875B2

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