Bromomethylcyclopropane → HCID 70097090, Verbindung
Reaktionsgleichung
[CH2:1]([O:3][C:4]([C:6]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][NH:8][N:7]=1)=[O:5])[CH3:2].Br[CH2:15][CH:16]1[CH2:18][CH2:17]1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[N:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])=[O:5])[CH3:2]Komponenten
3
Versuchsvorschrift
The product was obtained according to the method described in example 4, step 2 starting from 4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester and bromomethyl-cyclopropane as a mixture of regioisomers which were separated by silica gel chromatography using a heptane/ethyl acetate gradient to yield 179 mg (46%) of the desired regioisomer and 88 mg (23%) of 2-cyclopropylmethyl-4-nitro-2H-pyrazole-3-carboxylic acid ethyl ester.
Aufarbeitung
- customThe product was obtained
- customwere separated by silica gel chromatography