3-(Dimethylamino)pyrrolidine → 6-Cyclopropyl-N-[4-(3-dimethylamino-pyrrolidine-1-carbonyl)-pyridin-3-yl]-3-(pyrimidin-5-ylamino)-pyridine-2-carboximidic acid
Reaktionsgleichung
[CH3:1][N:2]([CH3:8])[CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.[CH:9]1([C:12]2[N:17]=[C:16]([C:18]([NH:20][C:21]3[CH:29]=[N:28][CH:27]=[CH:26][C:22]=3[C:23](O)=[O:24])=[O:19])[C:15]([NH:30][C:31]3[CH:32]=[N:33][CH:34]=[N:35][CH:36]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10]1>>[CH:9]1([C:12]2[N:17]=[C:16]([C:18](=[N:20][C:21]3[CH:29]=[N:28][CH:27]=[CH:26][C:22]=3[C:23]([N:5]3[CH2:6][CH2:7][CH:3]([N:2]([CH3:8])[CH3:1])[CH2:4]3)=[O:24])[OH:19])[C:15]([NH:30][C:31]3[CH:32]=[N:33][CH:34]=[N:35][CH:36]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10]1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
According to the general method described above (step 3), reaction of 3-dimethylamino-pyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (13%) as sticky yellow solid