2-Oxa-6-azaspiro[3.3]heptane → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2-oxa-6-aza-spiro[3.3]heptane-6-carbonyl)-pyridin-3-yl]-amide
Reaktionsgleichung
[CH2:1]1[C:4]2([CH2:7][NH:6][CH2:5]2)[CH2:3][O:2]1.[CH:8]1([C:11]2[N:16]=[C:15]([C:17]([NH:19][C:20]3[CH:28]=[N:27][CH:26]=[CH:25][C:21]=3[C:22](O)=[O:23])=[O:18])[C:14]([NH:29][C:30]3[CH:31]=[N:32][CH:33]=[N:34][CH:35]=3)=[CH:13][CH:12]=2)[CH2:10][CH2:9]1>>[CH2:1]1[C:4]2([CH2:7][N:6]([C:22]([C:21]3[CH:25]=[CH:26][N:27]=[CH:28][C:20]=3[NH:19][C:17]([C:15]3[C:14]([NH:29][C:30]4[CH:31]=[N:32][CH:33]=[N:34][CH:35]=4)=[CH:13][CH:12]=[C:11]([CH:8]4[CH2:10][CH2:9]4)[N:16]=3)=[O:18])=[O:23])[CH2:5]2)[CH2:3][O:2]1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
According to the general method described in step 3 of example 53, reaction of 2-oxa-6-aza-spiro[3.3]heptane with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (9%) as amorphous off-white solid.