Thionyl Chloride → HCID 67456441, Verbindung

HRID 2368765

Reaktionsgleichung

Reaktionsgleichung von HRID 2368765
O[CH:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.S(Cl)([Cl:15])=O>C(Cl)Cl>[Cl:15][CH:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 145153231-hydroxy-2,3-dihydro-1H-indene-5-carbonitrile

Produkt 1

HCID 67456441HCID 67456441, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1-Hydroxy-2,3-dihydro-1H-indene-5-carbonitrile (4.77 g, 30 mmol) was dissolved in 10 mL of methylene dichloride. While cooled on ice, thionyl chloride (6.6 ml, 90 mmol) was added dropwise within about 15 minutes. The solution was concentrated after being stirred for 3 hours. The residue was dissolved in ethyl acetate and the solution obtained was washed with cooled brine for 3 times, dried over anhydrous magnesium sulfate, and concentrated to obtain 1-chloro-2,3-dihydro-1H-indene-5-carbonitrile.

Aufarbeitung

  1. additionwas added dropwise within about 15 minutes
  2. concentrationThe solution was concentrated
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. customthe solution obtained
  5. washwas washed with cooled brine for 3 times
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-1bceab36026f4f35a34eaa2018214aca
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08703771B2

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