Hydrazine → HCID 67905363, Verbindung

HRID 2371421Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2371421
[NH2:1][NH2:2].[O:3]=[C:4]1[CH:9]([CH2:10][C:11](OC)=[O:12])[S:8](=[O:16])(=[O:15])[C:7]2[S:17][C:18]([S:20](=[O:23])(=[O:22])[NH2:21])=[CH:19][C:6]=2[NH:5]1>CO>[S:20]([C:18]1[S:17][C:7]2[S:8](=[O:16])(=[O:15])[CH:9]([CH2:10][C:11]([NH:1][NH2:2])=[O:12])[C:4](=[O:3])[NH:5][C:6]=2[CH:19]=1)(=[O:23])(=[O:22])[NH2:21]

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 86745510HCID 86745510, Verbindung

Produkt 1

HCID 67905363HCID 67905363, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Anhydrous hydrazine (1 ml) was added to a solution of methyl (2,3-dihydro-2,4,4-trioxo-6-sulfamoyl-1H-thieno[2,3-b][1,4]thiazin-3-yl)acetate (1.0 g) in methanol (10 ml) at ambient temperature with stirring. After 5-6 hours, the methanol was removed under reduced pressure and the residue was treated with water (10 ml). The pH was adjusted to 6.5 and the resulting precipitate was collected, rinsed with water and dried under vacuum to give 0.40 g (2,3-dihydro-6-sulfamoyl-2,4,4-trioxo-1H-thieno[2,3-b][1,4]thiazin-3-yl)acetic acid hydrazide, mp 230° C., dec.

Aufarbeitung

  1. customthe methanol was removed under reduced pressure
  2. additionthe residue was treated with water (10 ml)
  3. customthe resulting precipitate was collected
  4. washrinsed with water
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-17f5911b7ee34a7c88cb981e686592f3
Quelldatensatz
uspto-grants-1992_03
Patentnummer
US05093332

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