Ethanol → HCID 10489839, Verbindung

HRID 2371531Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2371531
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(O)C.[CH2:19]([NH:21][CH2:22]C)C.C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[CH3:19][N:21]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:22]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 8021DiethylamineHCID 516892Sodium BicarbonateHCID 563758(8-Bromooctyl)benzene

Produkt 1

HCID 10489839HCID 10489839, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To 538 mg of (8-bromooctyl)benzene were added 1 ml of ethanol and 1.05 ml of 50% aqueous diethylamine solution, and the mixture was stirred at a room temperature for 7.5 hours. To the mixture were added 30 ml of ethyl acetate and 5 ml of 5% sodium bicarbonate aqueous solution, and the resulting layers were separated. The organic layer was washed with water and a saturated sodium chloride aqueous solution, dried over magnesium sulfate, and evaporated under a reduced pressure. The residue was applied to a silica gel column and eluted with chloroform/methanol (9:1) to eliminate impurities appeared on the start point on thin layer chromatography. In this way, compound as colorless liquid, 378 mg of the title compound was obtained as colorless liquid.

Aufarbeitung

  1. customthe resulting layers were separated
  2. washThe organic layer was washed with water
  3. dry with materiala saturated sodium chloride aqueous solution, dried over magnesium sulfate
  4. customevaporated under a reduced pressure
  5. washeluted with chloroform/methanol (9:1)

Quellen und Nachweise

ORD-Eintrag
ord-e73c47a0085e45be878c3ccd2907d8c5
Quelldatensatz
uspto-grants-1992_03
Patentnummer
US05093370

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