Thionyl Chloride → 2-Pyridinecarboxylic acid, 3-(chlorocarbonyl)-, methyl ester
Reaktionsgleichung
[CH3:1][O:2][C:3]([C:5]1[N:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](O)=[O:8])=[O:4].S(Cl)([Cl:16])=O>>[CH3:1][O:2][C:3]([C:5]1[N:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([Cl:16])=[O:8])=[O:4]Komponenten
3
Versuchsvorschrift
A mixture of 2-methoxycarbonylnicotinic acid (4.0 g) and thionyl chloride (30 ml) is heated under reflux until homogeneous. The remaining thionyl chloride is distilled off in vacuo to give 2-methoxycarbonylnicotinoyl chloride.
Aufarbeitung
- temperatureis heated
- temperatureunder reflux until homogeneous
- distillationThe remaining thionyl chloride is distilled off in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-0893ef6b3df44f80bfd0ac00a4001767
- Quelldatensatz
- uspto-grants-1992_03
- Patentnummer
- US05098466
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