Thionyl Chloride → HCID 14946077, Verbindung

HRID 237235

Reaktionsgleichung

Reaktionsgleichung von HRID 237235
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:5][CH:4]=1.S(Cl)([Cl:16])=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10]([Cl:16])=[O:11])=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 257576p-Methoxyphenylpropionic acid

Produkt 1

HCID 14946077HCID 14946077, Verbindung

Versuchsvorschrift

Under an argon atmosphere, 2-(4-methoxyphenyl)propanoic acid (synthesized by the process of I. Shiina, et al., Eur. J. Org. Chem., 5887-5890 (2008)) (1.20 g, 6.66 mmol) was dissolved in thionyl chloride (6.00 mL, 82.6 mmol) and the solution was heated to reflux for 27 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to give the crude product of 2-(4-methoxyphenyl)propanoyl chloride (16) as a colorless oil. The product was used in the following reaction without further purification.

Aufarbeitung

  1. temperaturethe solution was heated
  2. temperatureto reflux for 27 hours
  3. concentrationthe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-aaa3d34f55d8495691df1b37dd6c408c
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642281B2

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