Phosphorus sulfide (P2S5) → HCID 19903350, Verbindung

HRID 2372374Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2372374
[CH3:1][CH:2]1[CH2:6][NH:5][C:4](=O)[CH:3]1[C:8]([O:10][CH2:11][CH3:12])=[O:9].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:14]>C1C=CC=CC=1>[CH3:1][CH:2]1[CH2:6][NH:5][C:4](=[S:14])[CH:3]1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Komponenten

4

Edukt 2

HCID 14817Phosphorus sulfide (P2S5)HCID 19903390HCID 19903390, Verbindung

Produkt 1

HCID 19903350HCID 19903350, VerbindungAusbeute 146,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

2.5 g of ethyl 4-methyl-2-oxopyrrolidine-3-carboxylate and 3.4 g of phosphorus pentasulfide were added to 50 ml of benzene and stirred at 50° C. for 1 hour. After cooling, the insoluble matters were filtered off and the filtrate was concentrated. The residue was purified by silica gel chromatography to thereby give 2.1 g of the title compound as an oily product.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe insoluble matters were filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe residue was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-ecc0947e65be4fd4b37b52f5debd7034
Quelldatensatz
uspto-grants-1992_03
Patentnummer
US05098919

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