p-Hydroxymethylbenzoylaminoethylamine acetate → N-t-Butyloxycarbonyl p-hydroxymethylbenzoylaminoethylamine

HRID 2372515Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2372515
[C:1]([OH:4])(=[O:3])C.[OH:5][CH2:6][C:7]1[CH:18]=[CH:17][C:10]([C:11]([NH:13][CH2:14][CH2:15][NH2:16])=[O:12])=[CH:9][CH:8]=1>CO>[C:7]([O:4][C:1]([NH:16][CH2:15][CH2:14][NH:13][C:11](=[O:12])[C:10]1[CH:9]=[CH:8][C:7]([CH2:6][OH:5])=[CH:18][CH:17]=1)=[O:3])([CH3:18])([CH3:8])[CH3:6]

Komponenten

3

Edukt 1

HCID 67918850p-Hydroxymethylbenzoylaminoethylamine acetate

Produkt 1

HCID 57104559N-t-Butyloxycarbonyl p-hydroxymethylbenzoylaminoethylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

p-Hydroxymethylbenzoylaminoethylamine acetate (0.30 g, 1.2 mmol) in methanol was treated with di-t-butyloxycarbonyl dicarbonate (0.38 g, 1.8 mmol). The solvent was evaporated, and the residue was dissolved in ether. The ether solution containing the product was filtered and reduced in volume leaving a white solid, which was removed by filtration and washed with petroleum ether. Yield 0.34 g (99%). Mp 117°-119°.

Aufarbeitung

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in ether
  3. additionThe ether solution containing the product
  4. filtrationwas filtered
  5. customleaving a white solid, which
  6. customwas removed by filtration
  7. washwashed with petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-2bca7e9d8e634dcc9d9251cacefb88d6
Quelldatensatz
uspto-grants-1992_03
Patentnummer
US05098996

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