Phosphorus oxychloride → 2-Butyl-4-chloro-6-methylpyrimidine
Reaktionsgleichung
[CH2:1]([C:5]1[NH:10][C:9](=O)[CH:8]=[C:7]([CH3:12])[N:6]=1)[CH2:2][CH2:3][CH3:4].P(Cl)(Cl)([Cl:15])=O>>[CH2:1]([C:5]1[N:10]=[C:9]([Cl:15])[CH:8]=[C:7]([CH3:12])[N:6]=1)[CH2:2][CH2:3][CH3:4]Komponenten
3
Versuchsvorschrift
The pyrimidinone from Example 3 2-n-butyl-6-methylpyrimidin-4(3H)-one is converted to the title compound upon treatment with phosphoryl chloride as described by Gabriel amd Colman (Ber. 1899, 32, 2921) and by Marshall and Walker (J. Chem. Soc., 1951, 1004).
Quellen und Nachweise
- ORD-Eintrag
- ord-4c1862e115cb4fe79b223dce9e83a049
- Quelldatensatz
- uspto-grants-1992_03
- Patentnummer
- US05100897
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