StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Sodium Hydroxide → 1-Oxo-2-ethoxy-2-(2-ethylphosphonoethyl)-1,2-diphenylethane

HRID 2372873
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2372873
[O:1]=[C:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:3]([O:20][CH2:21][CH3:22])([CH2:10][CH2:11][P:12]([O:17]CC)([O:14][CH2:15][CH3:16])=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(OC(C1C=CC=CC=1)C(=O)C1C=CC=CC=1)C.CCOP(OC=C)(OCC)=O.[OH-].[Na+]>C(O)C>[O:1]=[C:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:3]([O:20][CH2:21][CH3:22])([CH2:10][CH2:11][P:12]([OH:17])([O:14][CH2:15][CH3:16])=[O:13])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 14798Sodium HydroxideHCID 101778Benzoin ethyl etherHCID 573017Diethyl vinyl phosphateHCID 539682701-Oxo-2-ethoxy-2-(2-diethylphosphonoethyl)-1,2-diphenylethane

Produkt 1

HCID 539050581-Oxo-2-ethoxy-2-(2-ethylphosphonoethyl)-1,2-diphenylethane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702
Ethanol
Lösungsmittel

Versuchsvorschrift

1-Oxo-2-ethoxy-2-(2-diethylphosphonoethyl)-1,2-diphenylethane (25 g, prepared from benzoin ethyl ether and diethyl vinyl phosphonate as described in Example 3 of U.S. Pat. No. 4,082,821) is dissolved in ethanol (200 ml). Sodium hydroxide (20 g) is added to the solution and the mixture is heated under reflux for 3 hours. The ethanol is removed by rotary evaporation, water is added, and the mixture is washed with diethyl ether (4×100 ml) to remove unreacted starting material. Concentrated hydrochloric acid is added to the aqueous mixture until the pH is zero. The resulting mixture is washed with ether, water is evaporated and the residue is recrystallised from a mixture of acetone and ether to give 12.5 g of product, a compound of formula XVIII where R1 is ethoxy, R3 and Ar1 are each phenyl, R7 is --CH2CH2 -- and R8 is --CH2CH3.

Aufarbeitung

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. customThe ethanol is removed by rotary evaporation, water
  4. additionis added
  5. washthe mixture is washed with diethyl ether (4×100 ml)
  6. customto remove unreacted
  7. additionConcentrated hydrochloric acid is added to the aqueous mixture until the pH is zero
  8. washThe resulting mixture is washed with ether, water
  9. customis evaporated
  10. customthe residue is recrystallised from a mixture of acetone and ether

Quellen und Nachweise

ORD-Eintrag
ord-5ffa2cc03e754866a4fc310df225cf4b
Quelldatensatz
uspto-grants-1992_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05100987

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion