Benzoyl chloride → (4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl pentanoate

HRID 23729Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 23729
[C:1]([O:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH:14]([CH2:17][N:18]([CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[S:19]([NH:22][C:23](=[O:38])[C:24]2[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([C:34]([F:37])([F:36])[F:35])[CH:25]=2)(=[O:21])=[O:20])[CH2:13][CH2:12]1)(=[O:8])[C:2]1C=C[CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)CCCC.C(Cl)(=O)C1C=CC=CC=1>>[C:1]([O:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH:14]([CH2:17][N:18]([CH2:39][C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[S:19]([NH:22][C:23](=[O:38])[C:24]2[CH:25]=[C:26]([C:34]([F:35])([F:36])[F:37])[CH:27]=[C:28]([C:30]([F:33])([F:31])[F:32])[CH:29]=2)(=[O:21])=[O:20])[CH2:13][CH2:12]1)(=[O:8])[CH2:2][CH2:3][CH2:4][CH3:5]

Komponenten

4

Edukt 3

HCID 7412Benzoyl chlorideHCID 61186Valeryl chlorideHCID 22574465(4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl benzoate

Produkt 1

HCID 20757649(4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl pentanoate

Versuchsvorschrift

Following procedure to make (5), valeryl chloride was substituted for benzoyl chloride to give the title compound after purification. 1H NMR (500 MHz, DMSO-d6): δ 8.45 (s, 2H), 8.14 (s, 1H), 7.36 (d, 2H), 7.25 (t, 2H), 7.17 (t, 1H), 4.38 (s, 2H), 3.70 (d, 2H), 3.30 (water), 2.917 (d, 2H), 2.48 (DMSO), 2.22 (t, 2H), 1.62 (m, 2H), 1.52 (m, 2H), 1.45 (m, 2H), 1.37 (m, 1H), 1.26 (m, 1H), 1.22 (m, 2H), 0.82 (t, 3H), 0.63 (m, 4H).

Quellen und Nachweise

ORD-Eintrag
ord-d6f2eef6b0f444038a9660dc991fff7e
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06852738B2

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