p-Toluenesulfonic acid → HCID 57001829, Verbindung

HRID 2373064Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2373064
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH:10]([CH3:17])[CH:11](O)[CH2:12][C:13](=[O:15])[CH3:14])=[CH:4][CH:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][CH2:9][CH:10]([CH3:17])[CH:11]=[CH:12][C:13](=[O:15])[CH3:14])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 6101p-Toluenesulfonic acidHCID 146928186-(4-Fluorophenylthio)-4-hydroxy-5-methyl-2-hexanone

Produkt 1

HCID 57001829HCID 57001829, VerbindungAusbeute 96,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

1.00 Gram of 6-(4-fluorophenylthio)-4-hydroxy-5-methyl-2-hexanone was dissolved in 100 ml of toluene, and 0.02 g of p-toluene sulfonic acid was added thereto. The resulting mixture was refluxed for 1.5 hours with stirring. After having been cooled, the mixture was washed with a saturated aqueous sodium hydrogencarbonate solution and then saturated aqueous sodium chloride solution. Then the mixture was dried over anhydrous magnesium sulfate. Removing the solvent from the mixture under reduced pressure gave 1.08 g of 6-(4-fluorophenylthio)-5-methyl-3-hexen-2-one. (trans : cis =3.7 : 1) (purity: 83.5%). The yield was 96.8%.

Aufarbeitung

  1. temperatureThe resulting mixture was refluxed for 1.5 hours
  2. temperatureAfter having been cooled
  3. washthe mixture was washed with a saturated aqueous sodium hydrogencarbonate solution
  4. dry with materialThen the mixture was dried over anhydrous magnesium sulfate
  5. customRemoving the solvent from the mixture under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-cb590108440d402084f79974b9a0f3e8
Quelldatensatz
uspto-grants-1992_03
Patentnummer
US05101076

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