Ammonia → 7-Nitroquinazolin-4-amine

HRID 237317

Reaktionsgleichung

Reaktionsgleichung von HRID 237317
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH3:15]>CO>[N+:12]([C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH2:15])=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1)([O-:14])=[O:13]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 8306804-Chloro-7-nitroquinazoline

Produkt 1

HCID 136977987-Nitroquinazolin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 1.6 g of 4-chloro-7-nitroquinazoline in 50 ml 7N ammonia in methanol was stirred overnight at rt and concentrated to dryness. The solid was suspended in water, filtered, rinsed with water followed by ether and dried overnight in vacuum oven to provide 0.98 g of 7-nitroquinazolin-4-amine (Compound 98-2).

Aufarbeitung

  1. concentrationconcentrated to dryness
  2. filtrationfiltered
  3. washrinsed with water
  4. customdried overnight in vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-9c94a77e0d38476da509652811c7b21c
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642582B2

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