Hydrochloric Acid → Methyl 2-amino-5-methoxybenzoate

HRID 2373351

Reaktionsgleichung

Reaktionsgleichung von HRID 2373351
Cl.[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[CH3:14]O>>[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:14])=[O:6]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2779305-Methoxyanthranilic acid

Produkt 1

HCID 13052275Methyl 2-amino-5-methoxybenzoate

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Hydrogen chloride gas was bubbled through a solution of 2-amino-5-methoxybenzoic acid (5.0 g, 30 mmol) in MeOH (200 mL) for 30 minutes. The solution was heated at 60° C. overnight. The reaction was cooled and the solvent removed in vacuo. The residue was dissolved in water, basified with 5M NaOH and extracted twice with ether. The ether extracts were washed with 5M NaOH and water, dried (MgSO4), filtered and concentrated in vacuo to give i-e (4.25 g, 78%): MS m/z═182 (M+H).

Aufarbeitung

  1. temperatureThe reaction was cooled
  2. customthe solvent removed in vacuo
  3. dissolutionThe residue was dissolved in water
  4. extractionextracted twice with ether
  5. washThe ether extracts were washed with 5M NaOH and water
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo
  9. customto give i-e (4.25 g, 78%)

Quellen und Nachweise

ORD-Eintrag
ord-485b0003c27d4732bd3d76857f9246f2
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07459448B2

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