8-chloro-4-dimethylaminomethylene-1-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → HCID 59851940, Verbindung

HRID 2373367Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2373367
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=O)[C:10](=[CH:13]N(C)C)[CH2:9][C:8](=[O:17])[N:7]([CH3:18])[C:6]=2[CH:19]=1.[NH:20]([C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=1)[C:21]([NH2:23])=[NH:22]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[N:22]=[C:21]([NH:20][C:24]4[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=4)[N:23]=[CH:13][C:10]=3[CH2:9][C:8](=[O:17])[N:7]([CH3:18])[C:6]=2[CH:19]=1

Komponenten

3

Edukt 2

HCID 669346868-chloro-4-dimethylaminomethylene-1-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneHCID 178512548HCID 178512548, Verbindung

Produkt 1

HCID 59851940HCID 59851940, Verbindung

Versuchsvorschrift

In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-1-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-m) and 4-guanidinobenzoic acid were converted to I-7 (30%): HRMS Calcd. for C20H15ClN4O3: 395.0910, Found 395.0923.

Quellen und Nachweise

ORD-Eintrag
ord-f28af82618f646cf8f42f4ed00cc5cfd
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07459448B2

Notizen zur Reaktion

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