1-(4-(Trifluoromethyl)phenyl)piperazine → (2-Chloro-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

HRID 2374256

Reaktionsgleichung

Reaktionsgleichung von HRID 2374256
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[Cl:17][C:18]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][C:19]=1[C:20](O)=[O:21]>>[Cl:17][C:18]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:28])=[O:29])=[CH:23][C:19]=1[C:20]([N:12]1[CH2:13][CH2:14][N:9]([C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:15])[F:16])=[CH:8][CH:7]=2)[CH2:10][CH2:11]1)=[O:21]

Komponenten

3

Edukt 2

HCID 1217181-(4-(Trifluoromethyl)phenyl)piperazineHCID 23291322-Chloro-5-(methylsulphonyl)benzoic acid

Produkt 1

HCID 59793689(2-Chloro-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

Versuchsvorschrift

The title compound was prepared according to the procedure E described for example 9 from 1-(4-trifluromethylphenyl)piperazine (ABCR F07741NB, [30459-17-7] and 2-chloro-5-(methylsulfonyl)-benzoic acid (CAS: 89938-62-5); MS (m/e): 464.3 (M+NH4+).

Quellen und Nachweise

ORD-Eintrag
ord-095f8ee249ae4cd8ab3217eb8050aa8a
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07462617B2

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