Sodium Hydroxide → 6-Pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium Hydroxide	HCID 14798	—
Edukt	Ethyl 3-oxo-6-(pyridin-2-yl)-2,3-dihydropyridazine-4-carboxylate	HCID 20527880	—
Edukt	6-[4-(Benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid	HCID 69218872	—
Lösungsmittel	Hydrochloric Acid	HCID 313	—
Produkt	6-Pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid	HCID 69217260	96,2%

Reaktionsschritte

Working as in example 19 for the preparation of 6-[4-(benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid, but starting with 4 g of ethyl 6-pyridin-2-yl-3-oxo-2,3-dihydropyridazine-4-carboxylate, 49 cm3 of one molar sodium hydroxide solution and 50 cm3 of one molar hydrochloric acid solution, 3.44 g of 6-pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid were obtained in the form of a beige-colored solid melting at a temperature above 260° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07462613B2
Quelldatensatz	uspto-grants-2008_12
ORD ID	ord-942ff03a60c84e49a074b9376cf4a383
Quellennotiz	uspto-grants-2008_12