Hydrochloric Acid → 6-Pyridin-3-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Hydrochloric Acid	HCID 313	—
Edukt	Sodium Hydroxide	HCID 14798	—
Edukt	Ethyl 3-oxo-6-(pyridin-3-yl)-2,3-dihydropyridazine-4-carboxylate	HCID 20527882	—
Edukt	6-[4-(Benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid	HCID 69218872	—
Produkt	6-Pyridin-3-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid	HCID 69218608	92,3%

Reaktionsschritte

Working as in example 19 for the preparation of 6-[4-(benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid, but starting with 2 g of ethyl 6-pyridin-3-yl-3-oxo-2,3-dihydropyridazine-4-carboxylate, 24.5 cm3 of one molar sodium hydroxide solution and 25 cm3 of one molar hydrochloric acid solution, 1.65 g of 6-pyridin-3-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid were obtained in the form of a cream-colored solid melting at a temperature above 260° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07462613B2
Quelldatensatz	uspto-grants-2008_12
ORD ID	ord-3087780167e14b13a8ec2aee743f6664
Quellennotiz	uspto-grants-2008_12