1,1'-Carbonyldiimidazole → HCID 86697167, Verbindung

HRID 237506

Reaktionsgleichung

Reaktionsgleichung von HRID 237506
[Br:1][C:2]1[C:14]([CH3:15])=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8](O)=[O:9])=[CH:4][C:3]=1[CH3:16].C(N1C=CN=C1)([N:19]1C=CN=C1)=O.O.[OH-].[NH4+]>O1CCCC1>[Br:1][C:2]1[C:14]([CH3:15])=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([NH2:19])=[O:9])=[CH:4][C:3]=1[CH3:16]

Komponenten

5

Edukt 3

HCID 682631,1'-CarbonyldiimidazoleHCID 20990264HCID 20990264, VerbindungHCID 86589665Water ammonium hydroxide

Produkt 1

HCID 86697167HCID 86697167, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-(4-Bromo-3,5-dimethyl-phenoxy)-2-methyl-propionic acid (500 mg) is dissolved in 10 mL of tetrahydrofurane, 1,1′-carbonyldimidazole (217 mg) and 30% ammonium hydroxide water solution are added and the reaction mixture is stirred at room temperature for 3 h. The reaction mixture is concentrated under vacuum, ethyl acetate is added and the organic solution is washed with a 10% HCl water solution. The organic phase is separated, dried over sodium sulfate and concentrated under vacuum to give the title compound. Yield: 300 mg.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under vacuum, ethyl acetate
  2. additionis added
  3. washthe organic solution is washed with a 10% HCl water solution
  4. customThe organic phase is separated
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f4abee1dccff4f1590921d1abbbdd41a
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642585B2

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