4-(4-Nitrophenyl)oxazole → 4-(Oxazol-4-yl)aniline

HRID 2375444

Reaktionsgleichung

Reaktionsgleichung von HRID 2375444
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>[C].[Pd].C(O)C.O1CCCC1>[O:13]1[CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[N:11]=[CH:12]1

Komponenten

5

Edukt 2

HCID 145677974-(4-Nitrophenyl)oxazoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 223978534-(Oxazol-4-yl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 21873804Tetrahydrofuran ethanolLösungsmittel

Versuchsvorschrift

5% Palladium-carbon powder was added to an ethanol-tetrahydrofuran mixed suspension of 4-(4-nitrophenyl)-1,3-oxazol and stirred for 12 hours at room temperature in a hydrogen atmosphere. The reaction solution was filtered through Celite and the filtrate was evaporated under reduced pressure. The resulting crude product is purified with a silica gel column chromatography to obtain [4-(1,3-oxazol-4-yl)phenyl]amine (pale yellow solid). Electron Impact-MS(M)+: 160.

Aufarbeitung

  1. additionmixed
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe filtrate was evaporated under reduced pressure
  4. customThe resulting crude product is purified with a silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-1519ff411b454708a102c24fe406bc08
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07465748B2

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