1,3,5-Trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 4-(4-Bromo-3,5-dimethyl-phenyl)-1,3,5-trimethyl-pyrazole
Reaktionsgleichung
CC1(C)C(C)(C)OB([C:9]2[C:10]([CH3:16])=[N:11][N:12]([CH3:15])[C:13]=2[CH3:14])O1.[Br:18][C:19]1[C:24]([CH3:25])=[CH:23][C:22](I)=[CH:21][C:20]=1[CH3:27]>>[Br:18][C:19]1[C:24]([CH3:25])=[CH:23][C:22]([C:9]2[C:10]([CH3:16])=[N:11][N:12]([CH3:15])[C:13]=2[CH3:14])=[CH:21][C:20]=1[CH3:27]Komponenten
3
Versuchsvorschrift
The title compound is prepared from 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3,5-trimethyl-pyrazole and 2-bromo-5-iodo-1,3-dimethyl-benzene following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 7): tR=1.09 min; Mass spectrum (ESI+): m/z=293/295 (Br) [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-b00ba484e47d4481b0ce0ecc164820ae
- Quelldatensatz
- uspto-grants-2014_02