2-Iodo-1-methyl-1H-imidazole → 2-(4-Chloro-3,5-dimethyl-phenyl)-1-methyl-imidazole

Reaktionsgleichung

[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:18].I[C:20]1[N:21]([CH3:25])[CH:22]=[CH:23][N:24]=1>>[Cl:1][C:2]1[C:3]([CH3:18])=[CH:4][C:5]([C:20]2[N:21]([CH3:25])[CH:22]=[CH:23][N:24]=2)=[CH:6][C:7]=1[CH3:8]

Komponenten

Edukt 2

HCID 3358352-Iodo-1-methyl-1H-imidazole

HCID 532171282-(4-Chloro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Produkt 1

HCID 866973592-(4-Chloro-3,5-dimethyl-phenyl)-1-methyl-imidazole

Versuchsvorschrift

The title compound is prepared from 2-chloro-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene and 2-iodo-1-methyl-imidazole following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 7): tR=0.80 min; Mass spectrum (ESI+): m/z=221/223 (Cl) [M+H]+.

Quellen und Nachweise

ORD-Eintrag: ord-44ad746cb51945db9391ac7c5e9924e1
Quelldatensatz: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08642585B2

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