Dimethylformamide dimethyl acetal → HCID 86602114, Verbindung

HRID 2377047Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2377047
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>CN(C=O)C>[CH3:18][N:19]([CH3:21])/[CH:20]=[CH:1]/[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1

Komponenten

4

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 44549262HCID 44549262, Verbindung

Produkt 1

HCID 86602114HCID 86602114, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A mixture of ethyl 4-methyl-5-nitropyridine-2-carboxylate (39.5 g, 0.19 mol), dimethylformamide-dimethylacetal (DMF-DMA) (30.6 g, 0.26 mol, 1.35 eq) in DMF (470 mL) was heated to 90° C. for 30 min. The solvent was removed in vacuo. The residue (78 g) was used without further purification in the next step.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customThe residue (78 g) was used without further purification in the next step

Quellen und Nachweise

ORD-Eintrag
ord-b4dc6674623440ea8dd4409b12dd4645
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07468375B2

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