4-Iodo-2-methoxynicotinaldehyde → HCID 178494190, Verbindung
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:12])[C:7](=O)[C:8](=O)[CH3:9])([CH3:4])([CH3:3])[CH3:2].IC1C=CN=C(OC)C=1C=O.C(OC(C1[NH:30][C:31]([C:35]2[C:36]([O:42][CH3:43])=[N:37][CH:38]=[CH:39][C:40]=2[I:41])=[N:32]C=1C)=O)C>>[I:41][C:40]1[CH:39]=[CH:38][N:37]=[C:36]([O:42][CH3:43])[C:35]=1[C:31]1[NH:30][C:7]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:12])=[C:8]([CH3:9])[N:32]=1Komponenten
4
Versuchsvorschrift
2,3-Dioxo-butyric acid tert-butyl ester (0.293 g, 1.54 mmol) and 4-iodo-2-methoxy-pyridine-3-carbaldehyde (0.405 g, 1.54 mmol) were reacted as described for the synthesis of 2-(4-iodo-2-methoxy-pyridin-3-yl)-5-methyl-3H-imidazole-4-carboxylic acid ethyl ester to give the title material (0.303 g, 47%). 1H NMR (400 MHz, DMSO-d6) δ (ppm) 1.58 (s, 9H) 2.46 (s, 3H) 3.85 (s, 3H) 7.64 (d, J=5.31 Hz, 1H) 8.00 (d, J=5.31 Hz, 1H).