Methyl iodide → HCID 178483384, Verbindung

HRID 2378711Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2378711
[CH3:1][N:2]([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)[CH3:3].[CH3:14][I:15]>C(OCC)(=O)C>[I-:15].[NH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([CH2:4][N+:2]([CH3:14])([CH3:1])[CH3:3])=[N:6]1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 178483331(1H-Indazol-3-yl)-N,N-dimethylmethanamine

Produkt 1

HCID 178483384HCID 178483384, VerbindungAusbeute 97,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3-Dimethylaminomethyl-1H-indazole (25.6 g, 146 mmol) obtained in Step 2 was dissolved in ethyl acetate (350 mL), and the solution was added with methyl iodide (33.3 mL, 535 mmol), followed by stirring at room temperature overnight. The resulting precipitates were collected by filtration to obtain (1H-indazol-3-ylmethyl)trimethylammonium iodide (45.0 g, 97%).

Aufarbeitung

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-9d51dc26137e4f4caa4ab489dba6e440
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07470717B2

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