(+)-Benzyl glycidyl ether → HCID 68527184, Verbindung

HRID 237879Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 237879
[N:1]#[C:2][NH2:3].[Na].[CH2:5]([O:12][CH2:13][C@@H:14]1[CH2:16][O:15]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CO>[CH2:5]([O:12][CH2:13][C@H:14]1[O:15][C:2]([NH2:3])=[N:1][CH2:16]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

4

Edukt 2

HCID 146296(+)-Benzyl glycidyl etherHCID 57375518Cyanamidnatrium

Produkt 1

HCID 68527184HCID 68527184, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a vigorously stirred solution of sodium hydrogen cyanamide (1.95 g, 30.4 mmol) in methanol (30.5 mL) was added dropwise (S)-2-benzyloxymethyl-oxirane (5 g, 30.4 mmol) in methanol. The reaction mixture was stirred at room temperature overnight after which the reaction mixture was concentrated to remove methanol. Ethyl acetate was added (150 mL) along with 50 ml of water. The contents were transferred to a separatory funnel, the organic layer was removed, dried over Na2SO4 and concentrated under vacuum to give 6.01 g (96%) of the title compound.

Aufarbeitung

  1. concentrationwas concentrated
  2. customto remove methanol
  3. additionEthyl acetate was added (150 mL) along with 50 ml of water
  4. customThe contents were transferred to a separatory funnel
  5. customthe organic layer was removed
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-babb6067cdf046538ca41461844b2546
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642603B2

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