Toluene → [2,3-Quinoxalindiyl]bis(methylene) bisphosphonic acid tetramethyl ester

HRID 2379025

Reaktionsgleichung

Reaktionsgleichung von HRID 2379025
[N:1]1[C:10]2[C:5](=[CH:6]C=C[CH:9]=2)[N:4]=CC=1.C[O:12][P:13]([O:16][CH3:17])[O:14][CH3:15].[C:18]1(C)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:15][O:14][P:13]([CH2:6][C:5]1[C:10]([CH2:9][P:13](=[O:12])([O:16][CH3:17])[O:14][CH3:15])=[N:1][C:18]2[C:19]([N:4]=1)=[CH:20][CH:21]=[CH:22][CH:23]=2)(=[O:12])[O:16][CH3:17]

Komponenten

4

Edukt 3

HCID 1140TolueneHCID 7045QuinoxalineHCID 8472Trimethyl phosphite

Produkt 1

HCID 86747692[2,3-Quinoxalindiyl]bis(methylene) bisphosphonic acid tetramethyl ester

Versuchsvorschrift

This known compound is prepared by making a solution of quinoxaline (3.16 g, 10 mmol) in hot toluene (20 ml) and treating with trimethylphosphite (2.73 g, 22 mmol). The mixture is heated at reflux temperature for 24 hours. The cooled solution deposits [2,3-quinoxalindiyl]bis(methylene) bisphosphonic acid tetramethyl ester (2.70 g, m.p. 113°-114° C.) after recrystallization from toluene. V. A. Arbuzov et al. Izvest Acad. Nauk SSSR, 1961, 1016; 1954, E 868; (Chem Abstracts (CA) 55:27352b; CA 49:13222e) report a m.p. 115°-116° C.

Aufarbeitung

  1. customThis known compound is prepared
  2. temperatureThe mixture is heated
  3. temperatureat reflux temperature for 24 hours
  4. customThe cooled solution deposits [2,3-quinoxalindiyl]bis(methylene) bisphosphonic acid tetramethyl ester (2.70 g, m.p. 113°-114° C.) after recrystallization from toluene

Quellen und Nachweise

ORD-Eintrag
ord-f34d2c28a3e748239ebc0e43af627408
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05360797

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