6-(Hydroxymethyl)pyridine-2-carboxamide → 6-Formylpicolinamide

HRID 2379802Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2379802
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)=[O:1]

Komponenten

4

Edukt 1

HCID 149169816-(Hydroxymethyl)pyridine-2-carboxamide

Produkt 1

HCID 189539186-FormylpicolinamideAusbeute 61,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (100 g) and manganese dioxide (500 g) in chloroform (2 l) was heated under reflux for 48 hours. Manganese dioxide was removed by filtration and the filtrate was evaporated in vacuo to give 6-formyl-2-pyridinecarboxamide (60.46 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customManganese dioxide was removed by filtration
  4. customthe filtrate was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-da1ea1714b924300a6f6efc2cc8da7c0
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05364871

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