Amidinothiourea → 4-(6-Aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole

HRID 2379832Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2379832
Br.C([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13](=O)[CH2:14]Br)[N:8]=1)(=O)C.[NH2:17][C:18](=[N:20][C:21]([NH2:23])=[S:22])[NH2:19]>CO>[NH2:5][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[N:23]=[C:21]([N:20]=[C:18]([NH2:19])[NH2:17])[S:22][CH:14]=2)[CH:10]=[CH:11][CH:12]=1

Komponenten

4

Edukt 2

HCID 2724563AmidinothioureaHCID 189538712-(Acetylaminomethyl)-6-bromoacetylpyridine hydrobromide

Produkt 1

HCID 103997684-(6-Aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazoleAusbeute 42,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2-(acetylaminometyl)-6-bromoacetylpyridine hydrobromide (3.34 g) and diaminomethylenethiourea (1.01 g) in methanol (50 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected, dissolved in water (50 ml) and the solution was made basic with aqueous potassium carbonate. The separated product was collected and washed with water to give 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.90 g).

Aufarbeitung

  1. temperaturewas refluxed for 10 hours
  2. customThe resulting precipitate was collected
  3. dissolutiondissolved in water (50 ml)
  4. customThe separated product was collected
  5. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-c28ea22a0310457883012b15a9d1d9a1
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05364871

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