4-[(2-Acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide → 4-(2-Acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole

HRID 2379856Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2379856
Br.[C:2]([NH:5][CH2:6][C:7](=[NH:21])[S:8][CH2:9][C:10]([C:12]1[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=1)=O)(=[O:4])[CH3:3]>C(O)C>[C:2]([NH:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[N:21]=1)(=[O:4])[CH3:3]

Komponenten

3

Edukt 1

HCID 189537784-[(2-Acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide

Produkt 1

HCID 104023264-(2-Acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazoleAusbeute 74,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 4-[(2-acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide (11.4 g) in ethanol (100 ml) was refluxed for 2.5 hours. The resulting precipitate was collected by filtration and suspended in water (150 ml). The mixture was alkalized to pH 11 with a saturated aqueous potassium carbonate solution. The resulting precipitate was collected by filtration. Recrystallization from water afforded 4-(2-acetylaminomethylthiazol-4-yl )-2-(diaminomethyleneamino)thiazole (6.36 g). IR (Nujol): 3250, 1640 cm-1

Aufarbeitung

  1. temperaturewas refluxed for 2.5 hours
  2. filtrationThe resulting precipitate was collected by filtration
  3. filtrationThe resulting precipitate was collected by filtration
  4. customRecrystallization from water

Quellen und Nachweise

ORD-Eintrag
ord-b3be414c2eab48cea7e334e9f80409b6
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05364871

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