3-Bromo-1-propanol → 3-[(4,6-Diphenyl-2-pyridyl)oxy]-1-propanol

HRID 2380331Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2380331
[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][C:9](=[O:19])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:21][CH2:22][CH2:23][OH:24]>C(=O)([O-])[O-].[Ag+2].C1(C)C=CC=CC=1>[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:10]=[C:9]([O:19][CH2:21][CH2:22][CH2:23][OH:24])[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 2

HCID 123083-Bromo-1-propanolHCID 38462014,6-Diphenyl-2-pyridone

Produkt 1

HCID 189872833-[(4,6-Diphenyl-2-pyridyl)oxy]-1-propanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418647HCID 178418647, VerbindungKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

The procedure in Example 4 is followed but using 4,6-diphenyl-2-pyridone (15 g), freshly distilled 3-bromo-1-propanol (16.5 cc), silver carbonate (8.4 g) and toluene (600 cc). The reaction mixture is refluxed for 144 hours. The product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 7-3). (white solid; m.p.=94° C.)

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for 144 hours
  2. customThe product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 7-3)

Quellen und Nachweise

ORD-Eintrag
ord-4759aa999f6745418688925152ff27e7
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05366982

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