Hydrochloric Acid → 2-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole

HRID 2380625Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2380625
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[N:15]([CH3:16])[N:14]=[N:13][N:12]=2)=[CH:8][N:9]=1)(=O)C.Cl>C(O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[N:15]([CH3:16])[N:14]=[N:13][N:12]=2)=[CH:8][N:9]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 157291852-acetylamino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole

Produkt 1

HCID 157291862-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazoleAusbeute 48,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-acetylamino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole (2.0 g) in a mixture of ethanol (20 and aqueous 6N-hydrochloric acid (5 ml) was refluxed for 4 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was adjusted to pH 8 using aqueous sodium bicarbonate under ice cooling. The precipitates were collected by filtration, washed with water and the solid was recrystallized from ethanol to give 2-amino-5-(1-methyl -1H-tetrazol-5-ylthio)thiazole (0.81 g, yield: 48.5%).

Aufarbeitung

  1. temperaturewas refluxed for 4 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customthe solid was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-55c03fa3ef514421998b2f3f5596ea26
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05369107

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